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A drop in online sales and rising costs have helped to push Amazon to its first loss since 2015.
Online sales at the e-commerce giant slipped 3% in the first three months of the year, as the boom to its business from the pandemic starts to fade, the firm said Thursday.
Growth in other parts of its business, including cloud computing and advertising, remained strong.
But it is wrestling with the impact of rising costs and the Ukraine war.
Overall, Amazon reported a loss of $3.8bn, much of which was driven by a hit from its investment in electric carmaker Rivian.
It forecast sales growth of as little as 3% in the coming months.
"The pandemic and subsequent war in Ukraine have brought unusual growth and challenges," Amazon chief executive Andy Jassy said.
The firm's overall sales continued to rise, up 7% year-on-year to $116.4bn, powered by Amazon Web Services (AWS) - the company's cloud-computing division and reliable profit driver.
AWS revenues were up 37% year-on-year, while advertising revenue was also strong, rising 23%.
But elsewhere growth showed marked slowdown - especially in its international business, where sales sank 6%.
Expenses are also rising rapidly. Inflation added $6bn in expense in the quarter, executives said. The company is also facing a widening unionising drive in the US.
Shares in the firm sank more than 7% in after-hours trade. And concerns spread to other online retailers, adding to the fears in US markets, which have headed down in recent weeks.
Strong results from Apple helped to relieve some of those worries.
The iPhone maker said sales rose 9% year-on-year, to $97.3bn, and profits climbed more than 10% to $25bn.