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Italy's Enea Bastianini won his home race by claiming victory in the Italian Grand Prix at Emilia-Romagna.
Bastianini, 26, overtook Pramac Racing's Jorge Martin in the final lap to give Ducati their 100th MotoGP victory.
By finishing second, Martin extended his lead in the championship standings by 24 points.
It is Bastianini's second win of the year, having also triumphed at the British Grand Prix last month.
"Jorge was perfect for all the race and it was too difficult to try to overtake him," said Bastianini.
"In the last lap I saw a bit of space inside turn number four, I entered a bit on the limit but at the end I closed the line.
"It's incredible to win here in Misano in front of my friends."
Defending champion Francesco Bagnaia - Bastianini's Ducati team-mate - crashed out with seven laps remaining.
Spain's Marc Marquez, of Gresini Racing, finished third to lose further ground in his quest to win a seventh MotoGP title.
The 15th of 20 races in the season takes place next Sunday in Indonesia.