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Chase & Status and Becky Hill are the first headline acts announced for Radio 1's Big Weekend.
Rudimental and Ella Henderson will also hit the main stage on the opening Friday of the three-day festival in Stockwood Park, Luton, on 24-26 May.
Greg James, who revealed the names on his Breakfast show, will announce more acts over the coming days.
Last year Lewis Capaldi, Jonas Brothers, and The 1975 topped the bill in Dundee.
Dimension, Diplo, Kenya Grace and Hannah Laing are some of the artists announced for Friday's New Music stage line-up.
This year's Big Weekend will be the first time acts have played across all of the event's four stages for three full days - in previous years Friday was reserved for an 18-plus dance night.
Stockwood Park is in the south of the town, about a 10-minute drive from Luton FC's ground at Kenilworth Road.
The ground became football's most-memed away end when the club returned to the Premier League in 2023.
Luton is also the hometown of actress Emily Atack, presenter Stacy Dooley and cricketer Monty Panesar.
The festival returned in 2022 in Coventry after a break in the previous two years due to Covid-19.
There are 100,000 tickets available for 2024's Big Weekend, with a portion of those reserved for people from Luton and the surrounding area.
Last year, weekend tickets cost £29.00 plus a £4.50 booking fee while Friday tickets cost £18 with an additional booking fee of £2.50.