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Brentford produced a stunning first-half performance as they scored four goals in the first 35 minutes to condemn Manchester United to a humiliating defeat at Gtech Community Stadium.
Josh Dasilva put the hosts ahead when his strike from distance somehow eluded United goalkeeper David de Gea.
Mathias Jensen doubled the lead after dispossessing former Brentford player Christian Eriksen, with Ben Mee and Bryan Mbeumo goals putting Thomas Frank's side four up during an incredible first half in which they dismantled United in stunning fashion.
The defeat is United's seventh in a row on the road - their worst run since 1936 - while it is the seventh time they have conceded at least four goals in a league game since the start of last season.
While Brentford can bask in a historic win, United boss Erik ten Hag faces the unenviable task of lifting his players in time for the visit of Liverpool to Old Trafford on Monday, 22 August.
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From bad to worse for United
Having been deservedly beaten by Brighton last week, United sought to make a quick start but it was Brentford who found early joy as the visitors' defence crumbled in spectacular fashion against their high-pressing hosts.
De Gea, who for so long has been one of United's most consistent performers, was left red-faced when he allowed Dasilva's speculative shot from distance to slip underneath him and into the net, with Cristiano Ronaldo claiming he was fouled in the build-up.
Harry Maguire was then booked for a clumsy lunge on Dasilva, and while Mathias Jensen missed from the resultant free-kick, the Danish midfielder was celebrating two minutes later following another United mistake.
De Gea's pass to Eriksen on the edge of the United penalty area led to Jensen stealing the ball before slotting low into the net to double Brentford's lead.
After falling two behind to Brighton last week, it was another stern examination of United's character, but it only got worse as Brentford struck twice in the space of five minutes to move four clear.
Mee nodded home at the far post to make it three before Mbeumo finished off a rapid counter-attack when he controlled Ivan Toney's pass before curling the ball beyond a helpless De Gea to put the Bees four up after a scarcely believable 35 minutes.
Manager Ten Hag could barely have envisaged such a catastrophic start to his reign, and while there is still time for the Dutchman to transform their fortunes, the first two games of the season have underlined the daunting task facing the former Ajax boss at Old Trafford.
Brentford a breath of fresh air
While much of the post-match discussion will focus on United's problems, Brentford - like Brighton last week - deserve praise for their approach and execution.
From the first whistle, they tormented United, refusing to allow the visitors time on the ball and, crucially, took their chances to leave their opponents in the dust.
The first goal arrived when Jensen robbed Ronaldo inside the United half and fed the onrushing Dasilva. With Lisandro Martinez - subbed at half-time - slow to close off the space, Dasilva sent a low shot towards the goal that escaped De Gea's grasp.
That set the tone for the first half as Brentford ran riot. The impressive Jensen anticipated De Gea's risky pass to Eriksen and punished both players, before Toney used his height advantage to beat Martinez in the air and tee up Mee, who marked his home debut with a goal.
The fourth goal summed up the difference between the sides. After Jadon Sancho was muscled off the ball inside the Brentford box, the hosts pumped the ball long to Toney.
With United slow to react to the developing counter-attack, Toney slipped in Mbeumo, who shook off Luke Shaw and swept the ball home to spark delirious scenes among the home fans.
Ten Hag's response was to introduce Raphael Varane, Scott McTominay and Tyrell Malacia at the break, but with his players apparently in shock, United were unable to mount the miraculous comeback required to salvage something from the game as Brentford strolled to a victory that will live long in the memory.
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Brentford
Squad number1Player nameRaya
Squad number2Player nameHickey
Squad number30Player nameRoerslev
Squad number18Player nameJansson
Squad number16Player nameMee
Squad number3Player nameHenry
Squad number10Player nameDasilva
Squad number6Player nameNørgaard
Squad number8Player nameJensen
Squad number19Player nameMbeumo
Squad number17Player nameToney
Squad number11Player nameWissa
Squad number15Player nameOnyeka
Squad number26Player nameBaptiste
Squad number27Player nameJanelt
Squad number29Player nameBech Sørensen
Manchester United
Squad number1Player namede Gea
Squad number20Player nameDiogo Dalot
Squad number5Player nameMaguire
Squad number6Player nameMartínez
Squad number23Player nameShaw
Squad number14Player nameEriksen
Squad number17Player nameFred
Squad number25Player nameSancho
Squad number8Player nameBruno Fernandes
Squad number10Player nameRashford
Squad number7Player nameCristiano Ronaldo
Squad number12Player nameMalacia
Squad number19Player nameVarane
Squad number34Player namevan de Beek
Squad number36Player nameElanga
Squad number39Player nameMcTominay
Line-ups
Brentford
Formation 5-3-2
- 1Raya
- 2HickeySubstituted forBech Sørensenat 80'minutes
- 30Roerslev
- 18Jansson
- 16Mee
- 3Henry
- 10DasilvaSubstituted forJaneltat 62'minutes
- 6NørgaardSubstituted forOnyekaat 80'minutes
- 8JensenSubstituted forBaptisteat 74'minutes
- 19MbeumoSubstituted forWissaat 73'minutes
- 17Toney
Substitutes
- 11Wissa
- 14Ghoddos
- 15Onyeka
- 22Strakosha
- 23Lewis-Potter
- 24Damsgaard
- 26Baptiste
- 27Janelt
- 29Bech Sørensen
Man Utd
Formation 4-2-3-1
- 1de Gea
- 20Dalot
- 5MaguireBooked at 16mins
- 6MartínezSubstituted forVaraneat 45'minutes
- 23ShawSubstituted forMalaciaat 45'minutes
- 14EriksenSubstituted forvan de Beekat 87'minutes
- 17FredSubstituted forMcTominayat 45'minutesBooked at 82mins
- 25SanchoSubstituted forElangaat 60'minutes
- 8Bruno FernandesBooked at 90mins
- 10RashfordBooked at 89mins
- 7Cristiano Ronaldo
Substitutes
- 12Malacia
- 19Varane
- 22Heaton
- 29Wan-Bissaka
- 34van de Beek
- 36Elanga
- 37Garner
- 39McTominay
- 49Garnacho
Live Text
Match ends, Brentford 4, Manchester United 0.
Second Half ends, Brentford 4, Manchester United 0.
Foul by Scott McTominay (Manchester United).
Shandon Baptiste (Brentford) wins a free kick in the defensive half.
Bruno Fernandes (Manchester United) is shown the yellow card.
Bruno Fernandes (Manchester United).
(Brentford) wins a free kick in the defensive half.
Foul by Diogo Dalot (Manchester United).
Shandon Baptiste (Brentford) wins a free kick on the left wing.
Marcus Rashford (Manchester United) is shown the yellow card for a bad foul.
Foul by Marcus Rashford (Manchester United).
Shandon Baptiste (Brentford) wins a free kick in the attacking half.
Substitution, Manchester United. Donny van de Beek replaces Christian Eriksen.
Attempt saved. Cristiano Ronaldo (Manchester United) left footed shot from outside the box is saved in the centre of the goal. Assisted by Anthony Elanga.
Attempt saved. Yoane Wissa (Brentford) right footed shot from the right side of the box is saved in the centre of the goal. Assisted by Ivan Toney.
Corner, Brentford. Conceded by Harry Maguire.
Attempt blocked. Vitaly Janelt (Brentford) left footed shot from the right side of the six yard box is blocked.
Attempt blocked. Rico Henry (Brentford) left footed shot from outside the box is blocked.
Corner, Brentford. Conceded by Tyrell Malacia.
Scott McTominay (Manchester United) is shown the yellow card for a bad foul.
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