Covid-antibody therapy approved in UK

A new Covid treatment - that uses a pair of laboratory-made antibodies to attack the virus - has been approved for use in the UK.

The regulator said the drug Ronapreve had been shown to prevent infection and reduce the need for hospital treatment.

It was famously used as part of the suite of experimental medicines given to US President Donald Trump last year.

However, it is very expensive and likely to be reserved for those at greatest risk of becoming severely ill.

The antibody therapy attacks the virus, unlike other Covid treatments such as the steroid dexamethasone that calm the body's overactive immune system.

There had been concern the idea was a dud after trials failed when antibodies were taken from patients who had recovered from Covid.

However, the companies Regeneron and Roche tested monoclonal antibodies in the laboratory to find the two that were best able to stick to the virus.

This has proved far more effective, and the therapy continues to work against new variants.

The antibodies attach to the spike protein - the key the virus uses to unlock the doorway into our body's cells - on the surface of the coronavirus. This stops them infecting other cells to replicate and gives the body's own immune system more time to mount a response to the virus.

Dr Samantha Atkinson, from the UK's Medicines and Healthcare products Regulatory Agency, said: "We are satisfied that this treatment is safe and effective."

It is expected to be used by the NHS soon.

However, it will be expensive with estimates in the range of £1,000 to £2,000. All monoclonal antibodies - which are tiny pieces of biology, unlike the chemical drugs you buy in the pharmacy, are challenging and therefore expensive to make.

So it is still uncertain whether the antibody therapy will be offered to everyone, or reserved for those most likely to become severely ill due to a weak immune system.

Penny Ward, a professor in pharmaceutical medicine at King's College London, said it was "most likely" the treatment would be targeted at the most vulnerable.

And she said it could also used in people who may not respond to the vaccine, for example people being treated for cancer or after a transplant, if they are a close contact of someone infected.

Prof Martin Landray, who led trials of the therapy in hospitals, from the University of Oxford, said: "It would be hard to justify giving what are likely to be limited supplies of a relatively expensive treatment to huge numbers of people who are likely to get better on their own."

Health Secretary Sajid Javid said: "This is fantastic news... this treatment will be a significant addition to our armoury."