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Double-jabbed people in England who are close contacts of Covid cases will be told to take daily lateral flow tests for seven days from Tuesday.
Those who test positive, develop symptoms, or are unvaccinated should continue to self-isolate for 10 days, under new guidance.
It means people in close contact with suspected or confirmed Omicron variant cases no longer need to self-isolate.
NHS lateral flow tests are free from pharmacies or via online order.
People will not need to isolate if the test is negative and they have had at least two vaccine doses.
The government said the change in guidance "aims to reduce pressures on people's everyday lives by replacing the requirement for Omicron contacts to isolate for 10 days".
Anyone who has a positive result from a rapid test should take a confirmatory PCR test to verify the result, as well as continue to self-isolate.
They do not need to continue taking rapid tests during the isolation period.
If the PCR result comes back negative, contacts can leave self-isolation but should continue to take rapid lateral flow tests for seven days.
This change follows a significant rise in Omicron cases across the UK with the new variant expected to become the dominant strain by mid-December.
On Saturday, there were a further 54,073 new cases, including 633 of Omicron - although the real number of Omicron cases is estimated to be much higher.
Health and Social Care Secretary Sajid Javid said: "We are taking this proportionate and more practical measure to limit the impact on people's day-to-day lives while helping to reduce the spread of Omicron."