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The World Health Organization has said people who are unwell or at risk of developing severe Covid-19 should delay travel because of the Omicron variant.
In its latest travel advisory, the UN agency includes in that category people over 60, and those with conditions such as heart disease, cancer and diabetes.
It also restates its position that blanket travel bans do not prevent the spread of the variant.
South Africa alerted the world about the variant last week.
Many countries then proceeded to impose restrictions on travel from countries in southern Africa.
"Blanket travel bans will not prevent the international spread, and they place a heavy burden on lives and livelihoods," the WHO said in its statement.
"In addition, they can adversely impact global health efforts during a pandemic by disincentivising countries to report and share epidemiological and sequencing data."
UN Secretary General António Guterres said he was "deeply concerned" about the isolation of southern Africa, adding that "the people of Africa cannot be blamed for the immorally low level of vaccinations available".
Earlier, the head of the WHO, Tedros Adhanom Ghebreyesus, said there were still many questions regarding Omicron, including its transmission, the severity of the disease it might provoke, and the effectiveness of tests and vaccines.
In remarks to a closed-door meeting posted on the WHO website, Dr Tedros called on WHO member states to take "rational, proportional" measures.