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Marcus Smith is at fly-half and flanker Chandler Cunningham-South will make his first Test start when England face Eddie Jones' Japan in Tokyo on Saturday.
Steve Borthwick has picked a strong side with Cunningham-South, 21, in the XV for the first time, and Sale wing Tom Roebuck set for a debut from the bench.
Marcus Smith starts over namesake Fin, with Northampton's Premiership title winner among the replacements.
It is the first time England will play a Test match against the Brave Blossoms in Japan.
"We're looking forward to the challenge of playing Japan at their national stadium," said Borthwick.
"Conditions in Tokyo mean we'll need to be accurate, keep our discipline, and maintain a level of intensity in our performance from the first whistle to the last.
"We will need to be at our very best against an opponent who will want to play fast."
Hooker Jamie George captains the team with Bevan Rodd and Dan Cole alongside him in the front row.
It is George's first tour as captain having led England during the 2024 Six Nations.
"I feel comfortable and have felt comfortable from the start, it is easy when you have a group like his who are so keen and are having to be pulled back," George told BBC Sport.
"That's a nice place to be as a captain. I am also very lucky to have the coaching staff that we do who are so attentive and their attention to detail is absolutely second to none. They make my life very, very easy.
"I also have some very experienced guys, but also some young guys with huge leadership potential in Ben Earl, Marcus Smith and people like that, who you can give the reigns to a little bit. That is hugely exciting."
George Martin and Maro Itoje are the locks, with Sam Underhill and Ben Earl joining Cunningham-South in the back row.
The backline has a familiar look from the Six Nations, with Alex Mitchell at scrum-half, Henry Slade and Ollie Lawrence in the midfield, and Immanuel Feyi-Waboso, Tommy Freeman and George Furbank making up a lively back three.
"We had a big flip in emphasis on the way we want to attack [through the Six Nations]," said Slade.
"We realised if we did a little bit more focus on attack what we could do. Some of the players in the team have unbelievable X-factor, talent, speed and power. So it was just about getting the ball out to those boys.
"You've got boys like Manny [Feyi-Waboso] and Tommy Freeman in the outside channels. Some of those boys are unbelievable runners, so if we get the ball in the hand and let them do what they can do.
"We started to do that during the end of the campaign and long may it continue."
England: Furbank, Feyi-Waboso, Slade, Lawrence, Freeman, M Smith, Mitchell, Rodd, George (capt), Cole, Itoje, Martin, Cunningham-South, Underhill, Earl
Replacements: Dan, Marler, Stuart, Ewels, Curry, Randall, F Smith, Roebuck