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The Czech Republic's billionaire Prime Minister Andrej Babis and his ruling ANO party are set to lose their bid for re-election, partial results suggest.
With some 99% of voting districts reporting, Czech Television predicts two opposition coalitions will win 108 of 200 seats.
Both coalition groups have said they will not work with Mr Babis.
Ivan Bartos of the Pirates/Mayors coalition has said the opposition will start talks on forming a government.
According to a tally of results carried by Reuters news agency, the populist ANO won nearly 27.4% of the vote, with the centre-right coalition Spolu (meaning Together) winning 27.5% and the liberal Pirates/Mayors coalition PirStan taking 15.4%.
President Milos Zeman, the 77-year-old head of state, previously said he would give Mr Babis the chance to form a government if his party won the most seats.
But if the opposition coalitions keep to their pledge, it would be mathematically impossible for the leader and the ANO party to stay in power.
In office since December 2017, Mr Babis had sought another four years in power by pledging to further raise public sector wages and pensions, as well as criticising the EU and migration.
Opponents however have attacked his policies for raising the public debt, and have long criticised what they see as conflicts of interest related to the prime minister's business empire.
Mr Babis appeared in the Pandora Papers, a recent colossal leak of financial documents from offshore companies, which alleges he failed to declare an offshore investment company used to purchase two villas for £12m in the south of France.
After the leak, the prime minister insisted he had "never done anything wrong or illegal" and said the allegations published last week were an attempt to influence Saturday's vote.
He also faces accusations of mishandling the pandemic. According to Johns Hopkins University data, the Czech Republic has recorded 1.7 million cases and more than 30,000 deaths from the coronavirus.