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World number one Novak Djokovic is out of the Italian Open after a shock straight-set defeat by Chile's Alejandro Tabilo in the third round.
Tabilo needed just 67 minutes to beat a subdued Djokovic 6-2 6-3 for his first career win over a top-10 ranked opponent.
The 26-year-old was dominant throughout, breaking the Serb's serve four times and not conceding a single break point.
"It's incredible. I came on court just looking around and soaking it all in, trying to process everything. I'm trying to wake up right now," said world number 32 Tabilo.
"I was just trying to keep my nerves and keep swinging. Every time you feel like you are close to the end your arms get a little tighter.
"I was just trying not to think about it and take it point by point. It's crazy, I can't believe what's happened."
Tabilo is the first Chilean to beat a world number one since Fernando Gonzalez beat Roger Federer at the ATP Finals in 2007.
He will play Karen Khachanov in the next round after the Russian 16th seed beat Argentina's Francisco Cerundolo 6-2 6-4
It means six-time champion Djokovic will fail to reach at least the quarter-finals in Rome for the first time since 2006.
The 36-year-old, who is yet to reach a final in 2024, has played just six matches on clay this year as he prepares for the defence of his French Open title.
The tournament at Roland Garros begins on 26 May.
Elsewhere, Aryna Sabalenka eased through to the last 16 in Rome with a comfortable straight-set win over Dayana Yastremska.
The Belarusian Australian Open champion did not drop a single service game as she beat Ukrainian Yastremska 6-4 6-2 in one hour 28 minutes.
She will play Ukraine's two-time winner Elina Svitolina or Russia's Anna Kalinskaya in the next round.