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Venue: Sandy Park, Exeter Date: Saturday, 3 September Kick-off: 15:00 BST |
Coverage: Follow live text commentary on the BBC Sport website and app. |
Centre Tatyana Heard makes her first England appearance in three years in an experimental side for Saturday's World Cup warm-up against the United States.
Claudia MacDonald, who thought her career had been ended by a neck injury in 2021, starts on the wing.
Cath O'Donnell also returns from injury to fight for a place in the second row.
England's World Cup campaign in New Zealand begins against Fiji on 8 October, with Middleton due to name a 32-player squad on 20 September.
Number eight Poppy Cleall, fly-half Zoe Harrison, captain Emily Scarratt, wing Jess Breach and flanker Zoe Aldcroft keep their places after beating France in April.
Ellie Kildunne steps in for Helena Rowland at full-back, while Natasha Hunt is at scrum-half with Leanne Infante on the bench.
Hannah Botterman, Amy Cockayne and Bryony Cleall form an all-new front row as Rosie Galligan starts alongside O'Donnell at lock.
Aldcroft is in the back row with Poppy Cleall and 20-year-old Sadia Kabeya, who starts in place of Six Nations star Marlie Packer.
O'Donnell's Loughborough team-mate Morwenna Talling, 20, will be looking to make an impact off the bench in a competitive back five.
England will play Wales in their second warm-up game in Bristol on 14 September.
England: Kildunne; Breach, Scarratt (capt), Heard, MacDonald; Harrison, Hunt; Botterman, Cockayne, B Cleall, Galligan, O'Donnell, Aldcroft, Kabeya, P Cleall.
Replacements: Powell, Muir, Brown, Talling, Fleetwood, Infante, Rowland, Aitchison.