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Exeter Chiefs beat Saracens 29-12 in Saturday's top-of-the-table clash to leapfrog the visitors at the Premiership Women's Rugby summit.
Both teams won their opening four fixtures, but Saracens went into Saturday's game as league leaders having picked up two more bonus points.
But the Chiefs ended Saracens' 100% start by claiming a bonus-point victory at Sandy Park to go three points clear in top spot.
Merryn Doidge opened the scoring for the hosts before Saracens went in front through tries by Sarah McKenna and Akina Gondwe.
The Chiefs hit back through Flo Robinson and Alex Tessier kicked a penalty to give them a 17-12 lead at half-time.
They dominated the second half, with Eilidh Sinclair and Hope Rogers touching down to claim the extra point.
Round five continues on Sunday with fourth-placed Gloucester-Hartpury hosting bottom club Sale Sharks (14:00 GMT) while Leicester Tigers welcome Trailfinders Women (15:00 GMT).