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Great Britain's Jonnie Peacock faded in the final 50 metres as the former two-time Olympic champion finished fifth in the men's T64 100m final in Paris.
Costa Rica's Sherman Guity took gold with a Paralympic record time of 10.65.
Italian Maxcel Amo Manu finished second, with Germany's Felix Streng taking the bronze medal.
Peacock made a fine start out of the blocks, but was overtaken in the latter stages of the race and eventually crossed the line in 10.91 seconds.
Peacock, 31, won T44 gold at London 2012 and in Rio four years later, before taking bronze in the T64 event in Tokyo three years ago.