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Huddersfield scored twice in the final 15 minutes to deny dogged Derby a deserved point after the Rams were forced to play virtually the entire game with 10 men.
Richard Stearman was sent off for Wayne Rooney's Rams after just three minutes for a reckless lunge on Terriers midfielder Lewis O'Brien.
But Derby, seven points from safety in 23rd, gave as good as they got and Louie Sibley drilled inches wide before spurning a glorious second-half opportunity to put the visitors ahead.
Former Rams winger Duane Holmes broke the deadlock with a heavily-deflected opener and Jordan Rhodes' cool finish sealed the points as Huddersfield moved up to fifth place in the Championship.
The Terriers extended their unbeaten league run to 10 games thanks to their late double and it is now more than two months since they tasted defeat.
Their victory here was somewhat fortunate - the hosts' luck embodied in the strike from Holmes that took a wicked deflection off Krystian Bielik to loop over helpless Rams keeper Ryan Allsop.
The goal came out of nowhere, with Derby having completely snuffed Huddersfield out during the second half, and indeed limited them to little more than half-chances for the majority of the game.
Town's only real clear-cut chance had fallen to Holmes in the first half from O'Brien's clever first-time pass but, one-on-one with Allsop, he steered his finish wide -although the keeper might have got a touch.
Ultimately, however, Derby were made to pay for Stearman's early rush of blood against a side he spent 18 months with before joining the Rams last summer.
He was not the only Rams player at fault, Liam Thompson robbed by O'Brien after being put in trouble by a poor pass from keeper Allsop, before Stearman compounded the errors with a dangerous lunge.
Despite the dismissal, Derby grew into the game and while Sibley was unlucky to drill inches wide before the break, he later wasted a great chance with a heavy touch when clean through on Lee Nicholls.
After Holmes' slice of fortune, Rhodes added a second, tucking home the rebound after Allsop had parried from Danny Ward, to score his first Terriers goal since 2012 and end his barren second spell with the club.
For Derby boss Rooney, meanwhile, there were plenty of positives after just a second defeat in eight games and his side showed enough to suggest they can continue to make a fight of their survival bid, as long as the club's administrators can prove to the Football League that the club has a viable future.
Line-ups
Huddersfield
Formation 4-4-2
- 21Nicholls
- 20TurtonSubstituted forÁvilaat 56'minutes
- 4PearsonSubstituted forEitingat 45'minutes
- 32Lees
- 3Toffolo
- 16Thomas
- 6HoggSubstituted forRhodesat 72'minutes
- 8O'BrienBooked at 90mins
- 19Holmes
- 24Sinani
- 25Ward
Substitutes
- 2Ávila
- 9Rhodes
- 10Koroma
- 15High
- 18Blackman
- 23Sarr
- 48Eiting
Derby
Formation 4-4-1-1
- 31Allsop
- 2ByrneBooked at 90mins
- 16StearmanBooked at 3mins
- 33DaviesBooked at 73mins
- 26Buchanan
- 36EboseleBooked at 62mins
- 38Knight
- 42ThompsonSubstituted forStrettonat 80'minutes
- 17SibleySubstituted forCashinat 61'minutes
- 10Lawrence
- 48PlangeSubstituted forBielikat 45'minutes
Substitutes
- 3Forsyth
- 5Bielik
- 21Roos
- 22Bardell
- 32Ebiowei
- 34Stretton
- 41Cashin
Referee:Matt Donohue
Attendance:16,231
Live Text
Match ends, Huddersfield Town 2, Derby County 0.
Second Half ends, Huddersfield Town 2, Derby County 0.
Nathan Byrne (Derby County) is shown the yellow card for a bad foul.
Lewis O'Brien (Huddersfield Town) wins a free kick in the defensive half.
Foul by Nathan Byrne (Derby County).
Lewis O'Brien (Huddersfield Town) is shown the yellow card for a bad foul.
Foul by Lewis O'Brien (Huddersfield Town).
Festy Ebosele (Derby County) wins a free kick on the right wing.
Attempt saved. Danny Ward (Huddersfield Town) header from the centre of the box is saved in the centre of the goal. Assisted by Sorba Thomas with a cross.
Foul by Carel Eiting (Huddersfield Town).
Nathan Byrne (Derby County) wins a free kick in the defensive half.
Corner, Huddersfield Town. Conceded by Eiran Cashin.
Substitution, Derby County. Jack Stretton replaces Liam Thompson.
Goal! Huddersfield Town 2, Derby County 0. Jordan Rhodes (Huddersfield Town) left footed shot from the centre of the box to the centre of the goal.
Attempt saved. Danny Ward (Huddersfield Town) left footed shot from outside the box is saved in the centre of the goal. Assisted by Danel Sinani.
Attempt missed. Pipa (Huddersfield Town) right footed shot from outside the box is high and wide to the right. Assisted by Duane Holmes.
Jordan Rhodes (Huddersfield Town) wins a free kick in the attacking half.
Foul by Liam Thompson (Derby County).
Goal! Huddersfield Town 1, Derby County 0. Duane Holmes (Huddersfield Town) right footed shot from outside the box to the high centre of the goal. Assisted by Carel Eiting.
Attempt blocked. Duane Holmes (Huddersfield Town) right footed shot from outside the box is blocked. Assisted by Carel Eiting.