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Investors have continued to dump shares of First Republic amid fears the US bank could be the next to collapse.
The sell-off sent shares down more than 20% in morning trade on Wednesday.
That came after the price sank to a record low a day earlier, plunging nearly 50%, after the firm said it had lost $100bn in deposits in March.
First Republic has been under pressure since a series of bank failures in the US last month sparked fears of a wider crisis.
Founded in San Francisco in 1985, the bank is known for having a big mortgage lending business and a large stable of wealthy clients, many of whom had saved more money with the bank than would be guaranteed by the government.
It was seen as vulnerable to a bank run - and being squeezed by higher interest rates, as it is forced to pay more to keep deposits, while earning less on the home loans made when rates were lower.
Last month it received a $30bn influx from some of America's biggest banks, a rescue plan aimed at shoring up confidence in the lender, which had seemed to calm fears.
But the scale of the withdrawals revealed this week was even worse than investors had expected.
The bank's shares, which were worth more than $120 at the start of the year, ended Wednesday trading at roughly $8.
The bank - which was the 14th largest in America at the end of 2022 - has said it is exploring its options. US media outlets have reported it is considering sales of its assets and that regulators are on alert - but not prepared to step in yet.
"There can be no certainty that the bank will be able to take actions to strengthen our business within a time frame that is acceptable to the market or our regulators," the bank said on Tuesday,
"There can be no certainty as to the future of the bank if we are not able to do so."
Problems in the banking sector surfaced in the US earlier last month when Silicon Valley Bank, which was the country's 16th-largest lender, collapsed in the biggest failure of a US bank since 2008.
That was followed two days later by the failure of New York's Signature Bank.
Authorities stepped in to guarantee deposits beyond typical limits in an effort to head off further runs on bank deposits.
But the move, which the Federal Deposit Insurance Corp has estimated cost roughly $20bn, did not immediately prevent concerns from spreading.
In Europe, Swiss officials also brokered a rescue for troubled banking giant Credit Suisse, which saw 61.2bn Swiss francs ($69bn; £55.2bn) leave the bank in the first three months of the year.
Central banks around the world - including the US Federal Reserve and the Bank of England - have sharply increased interest rates as they try to curb inflation.
The moves have hurt the values of the large portfolios of bonds bought by banks when rates were lower.
Customers worried about the financial implications for Silicon Valley Bank abruptly pulled funds from their accounts, leading to its collapse. The episode also raised fears about the situation at other firms.