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Jacob Rees-Mogg has quit as business secretary, as Rishi Sunak begins to assemble his new team of cabinet ministers.
Justice Secretary Brandon Lewis is also out, after Mr Sunak took over from Liz Truss earlier as PM earlier.
Mr Rees-Mogg, who backed Ms Truss's leadership, is also a close ally of former Prime Minister Boris Johnson.
Mr Sunak has called for unity after becoming the third Tory leader in seven weeks.