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Hearings to confirm the first black woman justice to the highest US court began in Washington on Monday.
Ketanji Brown Jackson faces days of questioning before the Senate Judiciary Committee, the panel that will advance or sink her nomination.
If successful, Ms Jackson, 51, will be considered by the full Senate for a bid to replace retiring Justice Stephen Breyer.
Recent Supreme Court nominations have drawn partisan rancour in the chamber.
Announcing her nomination last month, US President Joe Biden called her "one of the nation's brightest legal minds". It was long past time that a black woman be confirmed to sit on the 233-year-old US Supreme Court, he suggested.
The court plays a key role in American life and is often the final word on highly contentious laws, disputes between states and the federal government, and final appeals to stay executions.
For any Supreme Court justice nomination, the president first chooses his preferred candidate and the Senate then votes to confirm that nominee, which requires a simple majority.
The Senate is currently split 50-50 between Democrats and Republicans, and Vice President Kamala Harris gets the deciding vote in the event of a tie.
The Biden administration has indicated it hopes to garner some Republican backing.
If confirmed, Ms Jackson would replace liberal Justice Breyer - for whom she once clerked - when he retires at the end of the court's term in June.
That means she will not shift the court's current 6-3 conservative majority.
Ms Jackson currently serves on the influential US Court of Appeals for the DC circuit. Three current Supreme Court justices previously served on that court.
The jurist has two degrees from Harvard University and once served as editor of the Harvard Law Review.
Mr Biden first promised to nominate a black woman to the top court two years ago while campaigning for the Democratic presidential nomination.
Black women make up about 3% of the federal judiciary, according to data from the Federal Judicial Center, the court system's research arm.
If confirmed, Ms Jackson would only be the third Black American to sit on the US Supreme Court, after justices Thurgood Marshall and Clarence Thomas.
Mr Thomas, 73, is the longest-serving Supreme Court associate justice. It emerged on Sunday that he is currently in hospital with an infection, but continues to work in absentia.