Olivia Newton-John's cancer-research legacy

Olivia Newton-John's family has asked people to donate to her cancer-research centre instead of sending flowers.

The singer and actress died at her home, in California, surrounded by her family and friends, on Monday.

She was diagnosed with breast cancer at the age of 44, in 1992, with treatment needed again in 2013 and 2018.

While she will be remembered for her acting and country-music career, the British-born star also led the way in cancer research and treatment.

Having moved to Australia, with her family at the age of six, she set up the Olivia Newton-John Cancer Wellness and Research Centre, in Melbourne, in 2012.

Beginning as an outpatient facility, it expanded to provide wards and hold patient trials, with six main research programmes developing treatments for breast, bowel, gastrointestinal-tract, lung, skin, liver and brain cancer.

Newton-John also advocated for cancer patients, focusing on their wellness and emotional support.

Breast Cancer UK head Thalie Martini said the Grease star had left an "incredible legacy".

The charity was "particularly grateful for Oliva Newton-John's commitment to awareness raising of this devastating disease".

If people were more aware of the early signs of breast cancer, 17,000 lives could be saved in the UK each year, it said.

And they could cut the risk of developing the cancer, with small steps such as "eating well, keeping physically active, limiting alcohol intake, minimising exposure to harmful chemicals, regularly checking their breasts and attending scheduled screening".

Newton-John used cannabis oil to treat her pain, sourced from her partner's farming business.

Just after she had discovered the cancer had spread to the base of her spine, she told the Cable News Network (CNN) she was "very lucky" to live where cannabis was legal.

"My dream is that in Australia soon it will be available to all the cancer patients and people going through cancer or any kind of disease that causes pain," she added.

According to Macmillan Cancer Support, there is no scientific proof cannabinoids can treat cancer - but research is continuing in the UK and around the world.

Newton-John also advocated herbal remedies, used holistic treatments such as acupuncture and massage therapy alongside treatment and adopted a vegan diet while having chemotherapy.

Charity Cancer Research UK says there is insufficient reliable evidence to use herbal remedies to treat cancer - although many take them to alleviate anxiety and relax.