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Champions Manchester City face West Ham away on the opening weekend of a 2022-23 Premier League campaign that will include a mid-season break for the World Cup in Qatar.
There will be no top-flight games after the weekend of 12-13 November until 26 December because of the World Cup.
The first fixture takes place on Friday, 5 August when Crystal Palace host Arsenal.
Liverpool play at promoted Fulham, with Nottingham Forest at Newcastle.
The World Cup, which will feature both England and Wales, starts on 21 November. The final is on 18 December, eight days before the Premier League season resumes.
There are no meetings between the Premier League's so-called 'big six' on weekend of 12-13 November - the one before the World Cup - following a request by the Football Association.
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First round of fixtures in full
5 August
Crystal Palace v Arsenal
6 August
Bournemouth v Aston Villa
Everton v Chelsea
Fulham v Liverpool
Leeds United v Wolverhampton
Leicester City v Brentford
Newcastle United v Nottingham Forest
Tottenham Hotspur v Southampton
7 August
Manchester United v Brighton
West Ham United v Manchester City
Break of more than six weeks
The 2022-23 season has been adjusted to accommodate the 2022 World Cup, which takes place in the middle of the domestic calendar.
It starts a week earlier than normal - 75 days after the final day of the 2021-22 campaign - and finishes a week later than usual on 28 May.
Fifa, world football's governing body, has already stipulated that players must be released on 14 November for the World Cup.
It means the mid-season break will last more than six weeks.
Games on 12-13 November before World Cup
Bournemouth v Everton
Brighton v Aston Villa
Fulham v Manchester United
Liverpool v Southampton
Manchester City v Brentford
Newcastle United v Chelsea
Nottingham Forest v Crystal Palace
Tottenham Hotspur v Leeds United
West Ham United v Leicester City
Wolverhampton v Arsenal
More to follow
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- Our coverage of your Premier League club is bigger and better than ever before - follow your team and sign up for notifications in the BBC Sport app to make sure you never miss a moment