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Hurricane Helene is one of the biggest ever storms to hit the US Gulf Coast, with wind gust speeds of 140 mph (225 km/h).
Florida's Lee County Sheriff's office shared footage of its rescue efforts, as flooding trapped some residents in their homes and vehicles.
The storm has now swept into Georgia and been downgraded but officials urge caution, saying the situation remains dangerous.
Three people are known to have died across the two states.