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Arsenal forward Bukayo Saka has been left out of the England squad that will face Andorra in Saturday's (17:00 BST) World Cup qualifier.
Atletico Madrid midfielder Conor Gallagher and Aston Villa striker Ollie Watkins have also been left out of the matchday squad, with Watkins returning home with a minor injury,
Speaking on Friday, head coach Thomas Tuchel revealed Saka had only completed one full training session during the week, with his omission from the squad to face Andorra likely to be linked to his fitness.
Saka, 23, is yet to play under Tuchel after missing the German's first camp through injury.
It remains to be seen whether Saka will play a part in the friendly against Senegal on 10 June, to add to his 43 caps for the Three Lions.
The winger missed three months of action between December and April with a hamstring injury, though he returned for the final two months of the campaign.
It was confirmed on Friday that Watkins would be leaving the group to return to England as a precaution because of a minor injury.
It is unclear at this stage whether Gallagher's omission is down to a fitness issue.
England are unbeaten in World Cup qualifying, winning both of their opening two matches against Latvia and Albania.