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Manchester City turned on the power to overcome a strong challenge from Southampton to secure a place in the FA Cup semi-finals at Wembley.
Saints were in contention for more than an hour in a tight encounter at St Mary's after Aymeric Laporte's own goal on the stroke of half-time cancelled out Raheem Sterling's early strike.
This FA Cup quarter-final turned on Mohammed Salisu's reckless challenge on Gabriel Jesus that saw Kevin de Bruyne restore City's lead from the penalty spot after 62 minutes, effectively ending Southampton's challenge.
Substitute Phil Foden's magnificent left-foot strike ended any faint hope of a Saints comeback and, as City took complete control, Riyad Mahrez added a fourth with 12 minutes left.
Man City get the job done
Manchester City ran out emphatic winners but until Salisu's needless intervention that resulted in De Bruyne's penalty they were threatening to pay a price for carelessness in possession.
Once De Bruyne had scored, however, City showed the quality and ruthlessness that has put them at the top of the Premier League and still in contention for the FA Cup and Champions League.
Manager Pep Guardiola can also introduce such strength off the bench, illustrated by the contributions from Foden and Mahrez.
Foden's 75th-minute goal was a thing of beauty, a rising drive from 20 yards that made a sweet thudding sounded that echoed around St Mary's once he struck with his left foot.
Mahrez scored one goal and could have had more but once again the great orchestrator was man-of-the-match De Bruyne, pulling the strings and stepping forward to beat Fraser Forster with a penalty that put City back in charge.
The fact that City can win so convincingly without touching the heights they are capable of will sound an ominous warning to anyone wanting to deprive them of any of those three major prizes they will contest between now and the end of the season.
Saints undone by Salisu challenge
Southampton were giving as good as they were getting until Mohammed Salisu's unnecessary tackle on Jesus, hardly in a dangerous position and with the game in the balance.
City gratefully accepted the gift and a vibrant atmosphere inside a packed St Mary's was instantly subdued as if both Southampton's players and fans sensed this was the decisive moment.
And so it proved as City took advantage of deflated Saints, who had played with so much energy and deserved so much credit for that first 62 minutes.
The high-intensity style that has made them such difficult opponents for so many teams this season was rushing City into errors in possession, one of which required a fine save from keeper Zack Steffen moments before De Bruyne put the visitors back in front.
Saints might even have scored a second equaliser when substitute Che Adams' point-blank effort was blocked by Steffen but this was an FA Cup quarter-final that had its destiny decided by Salisu's challenge.
This is not to say Southampton would have gone on to win but that incident changed the emphasis of the tie and Ralph Hasenhuttl's team had handed the initiative back to Manchester City, never the best of ideas.
Saints have contributed much to the FA Cup this season but all that remains now is for them to continue to ensure Premier League respectability and consolidation in a season that has contained plenty of promise.
Player of the match
De BruyneKevin De Bruyne
with an average of 7.23
Southampton
Squad number21Player nameLivramento
Squad number17Player nameS Armstrong
Squad number10Player nameAdams
Squad number2Player nameWalker-Peters
Squad number24Player nameElyounoussi
Squad number44Player nameForster
Squad number6Player nameOriol Romeu
Squad number18Player nameBroja
Squad number9Player nameA Armstrong
Squad number7Player nameLong
Squad number8Player nameWard-Prowse
Squad number19Player nameDjenepo
Squad number22Player nameSalisu
Squad number20Player nameSmallbone
Squad number5Player nameStephens
Squad number27Player nameDiallo
Manchester City
Squad number17Player nameDe Bruyne
Squad number26Player nameMahrez
Squad number47Player nameFoden
Squad number7Player nameSterling
Squad number27Player nameJoão Cancelo
Squad number2Player nameWalker
Squad number5Player nameStones
Squad number8Player nameGündogan
Squad number11Player nameZinchenko
Squad number16Player nameRodri
Squad number9Player nameGabriel Jesus
Squad number25Player nameFernandinho
Squad number6Player nameAké
Squad number14Player nameLaporte
Squad number13Player nameSteffen
Squad number10Player nameGrealish
Line-ups
Southampton
Formation 4-4-2
- 44Forster
- 21Livramento
- 5Stephens
- 22Salisu
- 2Walker-Peters
- 17S ArmstrongSubstituted forDjenepoat 83'minutes
- 6RomeuSubstituted forSmallboneat 88'minutes
- 8Ward-Prowse
- 24ElyounoussiSubstituted forDialloat 88'minutes
- 9A ArmstrongSubstituted forAdamsat 63'minutes
- 7LongSubstituted forBrojaat 63'minutes
Substitutes
- 10Adams
- 11Redmond
- 13Caballero
- 15Perraud
- 18Broja
- 19Djenepo
- 20Smallbone
- 27Diallo
- 43Valery
Man City
Formation 4-3-3
- 13SteffenBooked at 71mins
- 2Walker
- 5Stones
- 14LaporteSubstituted forAkéat 83'minutes
- 27CanceloSubstituted forZinchenkoat 82'minutes
- 17De Bruyne
- 16RodriSubstituted forFernandinhoat 83'minutes
- 8Gündogan
- 9Gabriel JesusSubstituted forMahrezat 63'minutes
- 10GrealishSubstituted forFodenat 64'minutes
- 7Sterling
Substitutes
- 6Aké
- 11Zinchenko
- 20Bernardo Silva
- 25Fernandinho
- 26Mahrez
- 33Carson
- 47Foden
Referee:Mike Dean
Attendance:29,702
Live Text
Match ends, Southampton 1, Manchester City 4.
Second Half ends, Southampton 1, Manchester City 4.
Attempt missed. Raheem Sterling (Manchester City) header from very close range misses to the right. Assisted by Ilkay Gündogan with a cross.
Foul by Phil Foden (Manchester City).
Jack Stephens (Southampton) wins a free kick in the defensive half.
Substitution, Southampton. William Smallbone replaces Oriol Romeu.
Substitution, Southampton. Ibrahima Diallo replaces Mohamed Elyounoussi.
Attempt missed. Riyad Mahrez (Manchester City) right footed shot from the right side of the box is close, but misses to the left. Assisted by Kevin De Bruyne.
Attempt saved. Riyad Mahrez (Manchester City) right footed shot from the right side of the box is saved in the bottom right corner. Assisted by Kevin De Bruyne.
Substitution, Southampton. Moussa Djenepo replaces Stuart Armstrong.
Substitution, Manchester City. Nathan Aké replaces Aymeric Laporte.
Substitution, Manchester City. Fernandinho replaces Rodri.
Substitution, Manchester City. Oleksandr Zinchenko replaces João Cancelo.
Attempt blocked. Stuart Armstrong (Southampton) left footed shot from outside the box is blocked. Assisted by Oriol Romeu with a headed pass.
Corner, Southampton. Conceded by Zack Steffen.
Corner, Southampton. Conceded by John Stones.
Goal! Southampton 1, Manchester City 4. Riyad Mahrez (Manchester City) left footed shot from the right side of the box to the bottom right corner. Assisted by Ilkay Gündogan.
Goal! Southampton 1, Manchester City 3. Phil Foden (Manchester City) left footed shot from outside the box to the bottom left corner.
Corner, Manchester City. Conceded by Valentino Livramento.
Attempt missed. Kyle Walker-Peters (Southampton) right footed shot from outside the box misses to the right.