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The Labour leader asked Rishi Sunak about Tory MP George Freeman who left his ministerial job as he could not afford his mortgage.
Sir Keir Starmer joked that "nobody could be failed to be moved" by the plight of the Norfolk MP struggling with mortgage payments.
The PM claimed the Labour frontbench was "confused" over tax cuts, while more people were applying for mortgages.
Starmer and Sunak clash on mortgages and cost of living at PMQs