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Jonas Vingegaard launched a stunning attack on the final climb of stage 11 to claim the Tour de France lead from defending champion Tadej Pogacar.
The 152km mountain stage from Albertville was set to be Pogacar's biggest test yet in this year's race.
And Jumbo-Visma's Vingegaard, who was 39 seconds adrift of Pogacar in third, burst clear for the 25-year-old's first Tour stage win atop Col du Granon.
The Dane leads by more than two minutes with Pogacar narrowly further back.
Asked if he could believe he had taken the yellow jersey, he replied: "No, it is really incredible. It is hard for me to put words on.
"This is what I always dreamt of, a stage in the Tour and now the yellow jersey."
More to follow.
Stage 11 results
1. Jonas Vingegaard (Den/Jumbo-Visma) 4hrs 18mins 02secs
2. Nairo Quintana (Col/Arkea Samsic) +59secs
3. Romain Bardet (Fra/DSM) +1min 10secs
4. Geraint Thomas (GB/Ineos Grenadiers) +1min 38secs
5. David Gaudu (Fra/Groupama-FDJ) +2mins 04secs
6. Adam Yates (GB/Ineos Grenadiers) +2mins 10secs
7. Tadej Pogacar (Slo/UAE Team Emirates) +2mins 51secs
8. Alexey Lutsenko (Kaz/Astana) +3mins 38secs
9. Steven Kruijswijk (Ned/Jumbo-Visma) +3mins 59secs
10. Warren Barguil (Fra/Arkea Samsic) +4mins 16secs
General classification after stage 11
1. Jonas Vingegaard (Den/Jumbo-Visma) 41hrs 29mins 59secs
2. Romain Bardet (Fra/DSM +2mins 16secs
3. Tadej Pogacar (Slo/UAE Team Emirates) +2mins 22secs
4. Geraint Thomas (GB/Ineos Grenadiers) +2mins 26secs
5. Nairo Quintana (Col/Arkea Samsic) +2mins 37secs
6. Adam Yates (GB/Ineos Grenadiers) +3mins 06secs
7. David Gaudu (Fra/Groupama-FDJ) +3mins 13secs
8. Aleksandr Vlasov (Rus/Bora-Hansgrohe) +7mins 23secs
9. Alexey Lutsenko (Kaz/Astana) +8mins 07secs
10. Enric Mas (Spa/Movistar) +9mins 29secs