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PwC's Chinese arm has been suspended from the country for six months over its work on the collapsed Chinese property giant Evergrande.
The Big Four accountancy firm is also being fined more than $62m (£47m) after Chinese authorities said it had helped cover up fraud at Evergrande.
The real estate firm went into liquidation in January under a mountain of debt.
PwC said it was "disappointed" by its Chinese unit's work, which it said had fallen "unacceptably below the standards" expected within PwC.
The Chinese authorities said PwC knew there were "major misstatements" in Evergrande's financial statements when it audited the firm.
As a result, the Chinese Ministry of Finance has imposed "administrative penalties" and suspended PwC's business for six months.
In addition, China's securities regulator has confiscated the revenue PwC earned auditing Evergrande and has also issued a fine.
An investigation by the regulator said PwC had "seriously eroded the basis of law and good faith, and damaged investors' interest".
In response to the penalties, PwC said it had taken "a number of accountability and remedial actions", including the sacking of six Chinese partners and the launch of a process to fine responsible team leaders.
An additional five staff have also left, and Hemione Hudson, PwC's global risk and regulatory leader, has been parachuted in to run the Chinese unit on an interim basis.
Evergrande which built property in more than 280 Chinese cities as well as branching out into other business sectors, teetered, then finally collapsed in January.
The Chinese authorities have accused Evergrande and its founder, Hui Ka Yan, of falsely inflating revenues at the firm to the tune of $78bn (£61.6bn) and imposed fines and bans on him personally as well as the business.