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The US central bank has pushed interest rates to the highest level in almost 15 years as it fights to rein in soaring prices in the world's largest economy.
The Federal Reserve announced it was raising its key rate by another 0.75 percentage points, lifting the target range to 3% to 3.25%.
Borrowing costs are expected to climb more - and remain high, the bank said.
The move comes despite mounting concern that the cost of controlling inflation could be a harsh economic downturn.
Federal Reserve chairman Jerome Powell has said the rate rises are necessary to slow demand, easing the pressures putting up prices and avoiding long-term damage to the economy.
Banks in nearly every country - with the big exceptions of Japan and China - are taking similar steps as they wrestle with their own inflation problems.
The Bank of England is widely expected to announce its seventh consecutive rate rise at its meeting on Thursday, while Indonesia and the Philippines are among the other countries also poised for increases.
Analysts are starting to worry that the global sweep of the rate hikes, which ripple out to the public in the form of more expensive mortgages, loans and credit card debt, could lead to greater economic slowdown than policymakers expect.
"That is definitely one of the downside risks - that the synchronised nature of the tightening could make it that much more powerful," said Brian Coulton, chief economist at Fitch Ratings.
How much will interest rates go up?
In the US, the Fed is raising rates at one of the fastest paces in its modern history, a sharp reversal after years of low borrowing costs.
Wednesday's increase - the fifth in a row - puts the rate the Fed charges banks to borrow from near zero at the start of the year to 3% for the first time since early 2008.
Forecasts released by the Fed on Wednesday show policymakers expect it to reach 4.4% by the end of the year - and rise to 4.6% in 2023, sharply higher than its prior forecasts.
"What is striking is the speed,"Mr Coulton said. "They're having to move very quickly ... and it means it's more likely to be a surprise to firms and households."
Uncertainty weighs heavily
New Yorker Sean V said he felt lucky that he bought a two-bedroom condo last year, before borrowing costs started their climb, locking in a mortgage rate around 2.6%.
But the 30-year-old works in the home loan industry, which has seen business plunge as mortgage rates cross 6% for the first time since 2008.
He said he feared losing his job "every single day" and was cutting back spending and scrapping holiday plans amid the uncertainty.
"I don't know what 2023 is going to bring," he said. "All of that weighs heavily - not just on me, on everybody."
"I don't know how stalling the economy is helping anyone."