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St Johnstone owner Adam Webb is being treated for cancer of the head and neck.
In an open letter,, external American lawyer Webb shared his health news and said his "prognosis is very good".
The club sacked manager Craig Levein earlier this week and majority shareholder Webb intends to lead the appointment of a new boss before taking medical leave, aiming to return in December.
"Since taking majority ownership of the club in July, I have taken an active role as owner and chairman," Webb said. "In a few weeks, the doctors tell me I will not be able to continue that active role.
"Prior to that date, we will have all of our top priorities in good shape, including the installation of our new head coach/manager. Indeed, I will be leading the effort to select our new coach in the coming days.
"CEO Fran Smith will serve as acting chairman while I take medical leave. I have requested that work on our priorities and improvements continue unabated. We've made a great start and we cannot pause now."
Webb said he will not be in Perth "for some time" and added that "several of my co-investors will be attending games this autumn... and I will be staying informed".
St Johnstone are 10th in the Scottish Premiership with one win from five games and visit Ross County on Saturday.